Christal Sohl, Ph.D.
Pronouns: Christal
Associate Professor of Biochemistry, MS/MA Advisor
San Diego
Primary Email: [email protected]
Phone/Fax
Primary Phone: 42039
Building/Location
5500 Campanile Dr
San Diego,
CA
92182
Mail Code: Links
Bio
In the Sohl lab, we are interested in probing mechanistic questions at the intersection of biochemistry and human disease. We use kinetic, structural, and cellular tools to address how altered enzyme activity impacts human health. In particular, we are interested in exploring the catalytic, structural and functional consequences of enzyme mutations implicated in diseases such as cancer. By understanding these molecular mechanisms of dysfunction, we can illuminate structure-function relationships, identify affected downstream pathways and ultimately develop platforms for targeted therapy. Students in the Sohl lab will gain interdisciplinary expertise in biochemistry, molecular biology and biophysics, including pre-steady-state kinetics, X-ray crystallography, spectroscopy, recombinant technology and cellular methods in a collaborative environment.
Areas of Specialization
Biochemistry, Molecular Biology, Biophysics, Pre-Steady-State Kinetics, X-Ray Crystallography, Spectroscopy, Recombinant Technology